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Description

The percentage of people living with Alzheimer's dementia increases dramatically with age

Its primary mechanisms include upregulation of vascular endothelial growth factor (VEGF) receptor expression, promotion of angiogenesis, and interaction with the nitric oxide system

Orbitrap-Fusion mass spectrometer (Thermo Finnigan, San Jose, CA) was used for mass spectrometry analysis

Metabolic analysis revealed that the source of the anti-ferroptosis effect of GCH1-overexpressing cells was BH4/BH2, supplementation with which rescued cell viability